Why 99% of bacteria die within 48 hours.

The average person tries 4.3 probiotic brands

Because 77% of generic strains fail to colonise. This is "Colonisation Resistance", your gut resits new bacteria. Without compatibility testing, you are gambling with your health.

Quantity matters

Most brands ship 5 billion CFUs, but research shows you need 50 billion CFUs minimum to establish new colonies. You have been underdosing by 10x. We deliver therapeutic doses scientifically verified to survive.

Mechanistic Engineering

Gut modelling used to be based on descriptive correlations, we've built the first ever combined commercial mechanistic engineering and AutoML based modelling tech. If our simulations predict a strain’s growth rate is zero in your gut, it doesn't go in your bottle.

The scale

7,302
‍Strains Modeled

Standard probiotics use the same few bacteria for everyone. We leverage the AGORA2 database (the best in class standard for human gut modeling) to reconstruct the metabolic potential of 7,302 human microbial strains. This is more accurate than any other method of understanding the gut by a highly significant margin.

1 Quad
‍Combinations

Finding your perfect formula is a combinatorial challenge with over 2⁵⁰ (1 quadrillion) possibilities. A brute-force approach is simply just impossible (it would take someone 31.7 million years to even count that high). Our model intelligently navigates this landscape, identifying the precise set of strains that maximizes immune modulation for your specific biology.

50k+
‍Training Sets

GutGutGoose's mechanistic-AI framework is trained on over 50,000 microbiomes. By using Flux Balance Analysis (FBA), we simulate how specific strains compete for resources in your unique ecosystem, achieving at least 2.3x superior colonization compared to hoping generic probiotics work.*

Created by scientists

Custom probiotics for gut health test and best probiotic for bloating with personalised solutions available.

In Silico Simulation

Close-up of a green eye with skin texture, relating to gut health and probiotics internally.

2⁵⁰ Search Space

Three women promoting custom probiotics and gut health test for personalized probiotics and bloating relief.

Rational Design

Created by artisans

Crafted by experts

Built by professionals

Created by artisans

Crafted by experts

Built by professionals

The Architecture

The Hybrid Mechanistic-AI Framework.

Generic probiotics have a 77% failure rate because they rely on guesswork.*

Here's what others don't do:

Sequence your complete microbiome, model 300+ strain interactions using neural networks, calculate colonization probability for each strain, then compound only the ones that will work in YOUR gut. The result? 2.3x better colonization than hoping generic probiotics work.We sequence your DNA, model 300+ strain interactions using neural networks, and calculate the exact colonization probability for your specific gut ecosystem.

We replaced the guesswork of standard probiotics with an industrial-grade computational stack. Our architecture orchestrates three distinct layers to translate raw DNA data into actionable engineering.

01. The Translation Layer

Bridging Taxonomy to Metabolism

Standard sequencing yields a list of names but ignores function, this makes modeling the gut very difficult since you're missing key information. We've built to bridge this gap. GutGutGoose ensures that "orphan reads" -the 20-30% of data typically discarded are integrated into your digital twin.

02. The Mechanistic Layer

Flux Balance Analysis (FBA)

While early attempts at gut modeling used statistical correlations, we use physics. Leveraging high performace parellel liniar optimisation, we run in silico simulations of ecological dynamics. We apply thermodynamic constraints to solve for metabolic fluxes. For instance if a strain’s predicted growth rate is < 10^-3 h^-1 in your specific gut environment, it is rejected. We don't guess if it will grow; we calculate it.

03. The Prescriptive Layer

Automated Machine Learning

We feed the simulation outputs into an AutoML pipeline to predict phenotypic outcomes. This connects the dots between raw bacterial counts and actual immune modulation, allowing us to optimize for the production of specific metabolites. This is part of how we've built first in class technology that makes Gutgutgoose the leader in understanding and adapting to the human gut.

The Mathematics

Solving the 2⁵⁰ question.

2⁵⁰

Search Space Complexity

Scanning Library...

If a library contains just 50 candidate strains, there are over 1 quadrillion possible combinations.

A human doctor cannot solve this.

A brute-force approach to probiotic design is statistically impossible. This is why generic formulations have high failure rates—they are shots in the dark. We use complex strategies for optimising objective functions to provably and effectively navigate this massive search space..

Unlike simple genetic algorithms, our system uses the right Bayesian optimisation algorithms to intelligently "learn" from every digital simulation. The AI iteratively selects the specific "Synbiotic" cluster- the exact strains plus the necessary prebiotic fibers- required to make the most impact.

We run 50-100 modelled trails of your formula so that the probiotics we compound are a totally unique mixture of bacteria mathematically proven to breach colonisation resistance- the result is "Rational Design". Gutgutgoose's models are a giant, first in the world breakthrough in how probiotics are done and proof of how effective science based customisation can be.

at least 2x the response rate of generic probiotcs.*

We test your bacteria, deliver therapeutic doses, then test again to prove colonisation. No other company verifies their probiotics actually survived. We show you the data.

Other probiotics?
Take them and hope.
GutGutGoose?
Semi-annual DNA proof showing exactly which strains became permanent residents versus temporary tourists. We track YOUR bacterial changes and evolve your formula based on what actually worked, with scheduled retests as part of your subscription- you don't have to hope- you can verify our science for yourself.

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Woman with healthy skin and hair, smiling subtly against a blue background, promoting custom probiotics solutions.

from supplement to saving lives

Current medicine is reactive; it waits for pathology. We are building the infrastructure for prevention. By banking your microbiome data and tracking its quarterly evolution against our database of 50,000+ samples, we are building a longitudinal dataset that detects metabolic dysregulation years before it manifests clinically.

GutGutGoose's vision is to one day decode early disease signals in your microbiome using breakthrough probiotic technology. Our research aims to predict chronic illnesses like Alzheimer's and cancer- decades before symptoms appear.

We're currently limited to 200 beta slots. We will not expand this waitlist as we don’t want to compromise customer care for patient volume.

Apply to join the waitlist

*Claims based on real science.

read the papers

The biggest leap in probiotic science
delivered to your door.

The Hybrid Mechanistic-AI Framework.

Solving the 2⁵⁰ question.

“I've reviewed their strain selection methodology. It's the most scientifically rigorous personalisation I've seen - metabolic modelling, colonisation prediction, advanced AI, strain-level precision. This is how probiotics should have always worked.

We test your bacteria, deliver therapeutic doses, then test again to prove colonisation. No other company verifies their probiotics actually survived. We show you the data.

Ready to feel something remarkable?

The biggest leap in probiotic science delivered to your door.

The Hybrid Mechanistic-AI Framework.

Solving the 250 question.

“I've reviewed their strain selection methodology. It's the most scientifically rigorous personalisation I've seen - metabolic modelling, colonisation prediction, advanced AI, strain-level precision. This is how probiotics should have always worked.

We test your bacteria, deliver therapeutic doses, then test again to prove colonisation. No other company verifies their probiotics actually survived. We show you the data.

Ready to feel something remarkable?

The biggest leap in probiotic science
delivered to your door.

Solving the 2⁵⁰ question.